Association between interleukin-1 beta polymorphism (+3953) and obesity.

  title={Association between interleukin-1 beta polymorphism (+3953) and obesity.},
  author={Maria Fernanda M{\^a}nica-Cattani and L Gonçalves Bittencourt and Maria Izabel de Ugalde Marques da Rocha and Tha{\'i}s Doeler Algarve and Luis Carlos Bodanese and Roberto Rech and Mariana Campos Martins Machado and Geisa Albertino Ferreira Santos and Maria Gabriela do Valle Gottlieb and Carla Helena Augustin Schwanke and Jacqueline da Costa Escobar Piccoli and M F F Duarte and Ivana Beatrice M{\^a}nica da Cruz},
  journal={Molecular and cellular endocrinology},
  volume={314 1},
It now appears that obesity is associated with a low-grade inflammation of white adipose tissue resulting from chronic activation of the innate immune system as interleukin-1 beta (IL-1). Previous investigations have described a positive association between IL-1 beta +3953 (C>T) gene polymorphism (rs 1143634) and obesity, suggesting functional effects on fat mass, fat metabolism and body mass. However, it is necessary to determine if these results occur in other populations and if they are… CONTINUE READING


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