Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs.

@article{Kersten2013AssociationBI,
  title={Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs.},
  author={Hege Kersten and Torgeir Bruun Wyller and Espen Molden},
  journal={Therapeutic drug monitoring},
  year={2013},
  volume={36 1},
  pages={
          125-30
        }
}
BACKGROUND To compare measures of anticholinergic activity between metabolic phenotypes of the polymorphic enzymes cytochrome P450 2D6 (CYP2D6) and CYP2C19 in the elderly patients exposed to anticholinergic agents. METHODS Long-term nursing home patients (n = 80) with an anticholinergic drug scale (ADS) score ≥3 were recruited from 22 nursing homes in Norway. Based on pharmacogenetic analyses of mutations encoding absent CYP2D6 or CYP2C19 metabolism, patients were divided into subgroups of… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

  • Clinical pharmacokinetics
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs.

  • British journal of clinical pharmacology
  • 2002
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: a randomized controlled trial.

  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2013
VIEW 1 EXCERPT

Drug metabolism in older people--a key consideration in achieving optimal outcomes with medicines.

  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2012
VIEW 1 EXCERPT

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