Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers.

@article{Lee2003AssociationBH,
  title={Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers.},
  author={Burton W Lee and L. A. J. London and Joseph Paulauskis and Jonny Myers and David C. Christiani},
  journal={Journal of occupational and environmental medicine},
  year={2003},
  volume={45 2},
  pages={118-22}
}
Pesticides, such as parathion, are metabolized by cytochrome p-450 system to paraoxon, which is a potent cholinesterase inhibitor. Paraoxonase (PON) catalyzes the hydrolysis of these toxic metabolites and protects against pesticide toxicity. A glutamine/arginine (Gln/Arg) polymorphism at amino acid position 192 of PON has been described. The Arg/Arg genotype is associated with higher serum paraoxonase activity compared to Gln/Gln. The Arg/Gln genotype is associated with intermediate serum PON… CONTINUE READING
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