Association between genetic polymorphisms of the β1-adrenergic receptor and sensitivity to pain and fentanyl in patients undergoing painful cosmetic surgery.

@article{Moriyama2013AssociationBG,
  title={Association between genetic polymorphisms of the β1-adrenergic receptor and sensitivity to pain and fentanyl in patients undergoing painful cosmetic surgery.},
  author={Ayako Moriyama and Daisuke Nishizawa and Shinya Kasai and Junko Hasegawa and Ken-ichi Fukuda and Makoto Nagashima and Ryoji Katoh and Kazutaka Ikeda},
  journal={Journal of pharmacological sciences},
  year={2013},
  volume={121 1},
  pages={48-57}
}
Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, and analyzed the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain and analgesic sensitivity. We examined associations between pain and fentanyl sensitivity and the two… CONTINUE READING

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