Association between genetic polymorphisms of glutathione S-transferase P1 and N-acetyltransferase 2 and susceptibility to squamous-cell carcinoma of the esophagus.

@article{Morita1998AssociationBG,
  title={Association between genetic polymorphisms of glutathione S-transferase P1 and N-acetyltransferase 2 and susceptibility to squamous-cell carcinoma of the esophagus.},
  author={Sadao Morita and Masaaki Yano and Toshimasa Tsujinaka and Atsuko Ogawa and Megumi Taniguchi and Kunihiko Kaneko and Hitoshi Shiozaki and Yuichiro Doki and Masashi Inoue and Morito Monden},
  journal={International journal of cancer},
  year={1998},
  volume={79 5},
  pages={517-20}
}
We examined the effect of genetic polymorphisms of phase-II enzymes, glutathione S-transferase P1 (GSTP1) and N-acetyltransferase2 (NAT2) on susceptibility to esophageal squamous-cell carcinoma To determine the genotypes of the 2 polymorphisms, PCR-based analysis was performed on samples from 66 Japanese patients who had been histologically diagnosed as having esophageal squamous-cell carcinoma, and 164 healthy Japanese controls. The frequency of the AA genotype of GSTP1 was significantly… CONTINUE READING

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