Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients.

@article{Mangoni2011AssociationBG,
  title={Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients.},
  author={Monica Mangoni and Simonetta Bisanzi and Francesca Carozzi and Cristina Sani and Giampaolo Biti and Lorenzo Livi and Emanuela Barletta and Adele Seniori Costantini and Giuseppe Gorini},
  journal={International journal of radiation oncology, biology, physics},
  year={2011},
  volume={81 1},
  pages={52-8}
}
PURPOSE Clinical radiosensitivity varies considerably among patients, and radiation-induced side effects developing in normal tissue can be therapy limiting. Some single nucleotide polymorphisms (SNPs) have been shown to correlate with hypersensitivity to radiotherapy. We conducted a prospective study of 87 female patients with breast cancer who received radiotherapy after breast surgery. We evaluated the association between acute skin reaction following radiotherapy and 11 genetic… CONTINUE READING

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