Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma.

@article{Nogueira2015AssociationBG,
  title={Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma.},
  author={Guilherme Augusto Silva Nogueira and Gustavo J Lourenço and Camila Borges Martins de Oliveira and Fernando Augusto Lima Marson and Leisa Lopes-Aguiar and Ericka Francislaine Dias Costa and Tathiane Regine Penna Lima and Vitor Teixeira Liutti and Frederico Leal and Vivian Castro Antunes Santos and Jos{\'e} Augusto Rinck-Junior and Carmen S P Lima},
  journal={International journal of cancer},
  year={2015},
  volume={137 4},
  pages={810-8}
}
We examined the influence of MLH1 c.-93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A and EXO1 c.1765G>A polymorphisms, involved in DNA mismatch repair (MMR), on head and neck (HN) squamous cell carcinoma (SCC) risk and prognosis. Aiming to identify genotypes, DNA from 450 HNSCC patients and 450 controls was analyzed by PCR-RFLP or real time PCR. MSH2 GG plus MSH3… CONTINUE READING