Association between genes encoding components of the IL-4/IL-4 receptor pathway and dermatitis in children.

@article{Hussein2014AssociationBG,
  title={Association between genes encoding components of the IL-4/IL-4 receptor pathway and dermatitis in children.},
  author={Yousri Mostafa Hussein and Sally M Shalaby and Amani Nassar and Saad S. Alzahrani and Ayman Alharbi and Maha A. Nouh},
  journal={Gene},
  year={2014},
  volume={545 2},
  pages={
          276-81
        }
}
OBJECTIVE To determine whether IL-4, IL-4Rα and STAT6 polymorphisms are associated with susceptibility to dermatitis in Egyptian children. METHODS We genotyped three groups of children, consisting of 106 atopic dermatitis (AD) children, 95 non-AD children, and 100 of healthy controls, for IL-4 (-590 C/T), (-33 C/T), IL-4Rα (I50V), (Q576R) and STAT6 (2964 G/A), (2892 C/T) gene polymorphisms using PCR-RFLP assay. Total serum IgE and serum IL-4 levels were detected by ELISA. RESULTS There was… CONTINUE READING
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