Association between gastroesophageal reflux and pathologic apneas in infants: a systematic review

@article{Smits2014AssociationBG,
  title={Association between gastroesophageal reflux and pathologic apneas in infants: a systematic review},
  author={Marije J. Smits and Michiel P. van Wijk and Miranda W. Langendam and Marc A. Benninga and Merit M Tabbers},
  journal={Neurogastroenterology \& Motility},
  year={2014},
  volume={26}
}
In infants, apneas can be centrally mediated, obstructive or both and have been proposed to be gastroesophageal reflux (GER) induced. Evidence for this possible association has never been systematically reviewed. 
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24 Citations
Background Citations
5
Results Citations
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24 Citations

Citation Type

Citation Type

Cardiorespiratory events in infants with gastroesophageal reflux symptoms: Is there any association?
  • F. Cresi, D. Martinelli, +6 authors A. Coscia
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2018
TLDR
Evaluated the relationships between CR and GER events in infants admitted to Neonatal Intensive Care Unit, leading to over‐prescription of drugs and delayed discharge.
Etiologies of apnea of infancy
To date there are limited data in the literature to guide the initial evaluation for etiologies of apnea in full‐term infants born at greater than or equal to 37 weeks conceptional age (apnea of…
Apnea in preterm neonates: what's the role of gastroesophageal reflux? A systematic review.
  • P. Quitadamo, V. Giorgio, +4 authors S. Salvatore
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2020
GOR(D) and Apnoea
TLDR
Empirical treatment for GOR is not recommended due to lack of evidence of efficacy and possible pharmacologically related adverse events, so oesophageal impedance with simultaneous polysomnography can better demonstrate the temporal association in selected patients but should be reserved to severe or recurrent otherwise unexplained respiratory events.
Gastroesophageal Reflux Disease (GERD) in Children
Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe?
TLDR
Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections, bacterial overgrowth, adverse bone health, food allergy and drug interactions.
Apnea in the term infant.
Combined therapy in gastro-esophageal reflux disease of term neonates resistant to conservative therapy and monotherapy: a clinical trial
TLDR
Combination of each acid suppressant with metoclopramide led to higher response rate in comparison with monotherapy used before intervention, but it was significantly higher in group A (> 90%).
Gastroesophageal reflux related to respiratory inhibition after crying and feeding hypoxemia in infants
  • H. Minowa, Reiko Tamura, +4 authors Ayako Ohgitani
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
TLDR
In the infants with RIAC and feeding Hypoxemia, some show severe hypoxemia and bradycardia caused by GER, and medical staff caring for infants should note the presence of RIACand feeding hypoxemic.
Respiratory inhibition after crying or gastroesophageal reflux and feeding hypoxemia in infants
  • H. Minowa
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
TLDR
Medical staff caring for infants should note the presence of RIAC, feeding hypoxemia, and RIGER, which are significantly associated with each other.
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References

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TLDR
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