Association between functional EGF+61 polymorphism and glioma risk.

  title={Association between functional EGF+61 polymorphism and glioma risk.},
  author={Bruno M Costa and Paulo Ferreira and Sandra M{\'a}rcia Carvalho Ribeiro Costa and Paulo Canedo and Pedro Oliveira and Ana Silva and Fernando Pardal and Gianpaolo Suriano and Jos{\'e} Carlos Machado and Jos{\'e} Manuel Lopes and Rui Manuel Reis},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 9},
PURPOSE Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61 in glioma susceptibility and prognosis. EXPERIMENTAL DESIGN A case-control study involving 197 glioma patients and 570 controls was done. Univariate and multivariate logistic regression analyses were used to calculate odds ratio (OR… CONTINUE READING


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