Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer.

@article{Yao2004AssociationBE,
  title={Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer.},
  author={James C. Yao and Liwei Wang and Daoyan Wei and Weida Gong and Manal Ismaeel Hassan and T. T. Wu and Paul R. W. Mansfield and Jaffer A. Ajani and Keping Xie},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 12 Pt 1},
  pages={4109-17}
}
The biological and clinical behaviors of cancer are affected by multiple molecular pathways that are under the control of transcription factors. Improved understanding of how transcription factors affect cancer biology may lead to improved ability to predict clinical outcome and discovery of novel therapeutic strategies. We evaluated the relationship between Sp1 and vascular endothelial growth factor (VEGF) expression, as well as their effect on survival in 86 cases of resected human gastric… CONTINUE READING
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p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular 4116 VEGF Expression by Sp1 in Human Gastric

  • J Milanini, F Vinals, J Pouyssegur, G. Pages
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