Association between expression of the H histo-blood group antigen, alpha1,2fucosyltransferases polymorphism of wild rabbits, and sensitivity to rabbit hemorrhagic disease virus.

@article{Guillon2009AssociationBE,
  title={Association between expression of the H histo-blood group antigen, alpha1,2fucosyltransferases polymorphism of wild rabbits, and sensitivity to rabbit hemorrhagic disease virus.},
  author={Patrice Guillon and Nathalie Ruvo{\"e}n-Clouet and B{\'e}atrice le Moullac-Vaidye and St{\'e}phane Marchandeau and Jacques Le Pendu},
  journal={Glycobiology},
  year={2009},
  volume={19 1},
  pages={21-8}
}
RHDV (rabbit hemorrhagic disease virus) is a highly virulent calicivirus that has become a major cause of mortality in wild rabbit populations (Oryctolagus cuniculus). It binds to the histo-blood group antigen (HBGA) H type 2 which requires an alpha1,2fucosyltransferase for its synthesis. In rabbit, three alpha1,2fucosyltransferases genes are known, Fut1, Fut2, and Sec1. Nonfunctional alleles at any of these loci could potentially confer resistance to RHDV, similar to human FUT2 alleles that… CONTINUE READING
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