Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age.

@article{Leuchter2014AssociationBE,
  title={Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age.},
  author={R. Ha-Vinh Leuchter and Laura Gui and Antoine Poncet and Cornelia Franziska Hagmann and Gregory A. Lodygensky and Ernst Martin and Brigitte M Koller and Alexandra Darque and Hans Ulrich Bucher and Petra Susan H{\"u}ppi},
  journal={JAMA},
  year={2014},
  volume={312 8},
  pages={
          817-24
        }
}
IMPORTANCE Premature infants are at risk of developing encephalopathy of prematurity, which is associated with long-term neurodevelopmental delay. Erythropoietin was shown to be neuroprotective in experimental and retrospective clinical studies. OBJECTIVE To determine if there is an association between early high-dose recombinant human erythropoietin treatment in preterm infants and biomarkers of encephalopathy of prematurity on magnetic resonance imaging (MRI) at term-equivalent age… CONTINUE READING
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