Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

@article{Vila1994AssociationBD,
  title={Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.},
  author={Jordi Vila and Joaquim Ruiz and Francesc Marco and Anna Barcel{\'o} and Pilar Go{\~n}i and Ernest Giralt and Teresa Jim{\'e}nez de Anta},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 10},
  pages={2477-9}
}
The mutations in the quinolone resistance-determining region of the gyrA and gyrB genes from 27 clinical isolates of Escherichia coli with a range of MICs of ciprofloxacin from 0.007 to 128 micrograms/ml and of nalidixic acid from 2 to > 2,000 micrograms/ml were determined by DNA sequencing. All 15 isolates with ciprofloxacin MICs of > or = 1 micrograms/ml showed a change in Ser-83 to Leu of GyrA protein, whereas in clinical isolates with a MIC of > or = 8 micrograms/ml (11 strains), a double… CONTINUE READING

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The molecular basis of quinolone action

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