Association between depressive behavior and absence of serotonin–dopamine interaction in the nucleus accumbens

@article{Zangen2001AssociationBD,
  title={Association between depressive behavior and absence of serotonin–dopamine interaction in the nucleus accumbens},
  author={Abraham Zangen and Rachel A Nakash and David H. Overstreet and Gal Yadid},
  journal={Psychopharmacology},
  year={2001},
  volume={155},
  pages={434-439}
}
Rationale: Current hypotheses on the etiology of depression attribute the disorder to alterations in serotonin and norepinephrine neurotransmission. However, the relationship between these alterations and depressive behavior is poorly understood. Conversely, an interaction between the serotonergic and dopaminergic systems in the nucleus accumbens has been established. Since motivation and hedonia have been associated with dopamine release in the nucleus accumbens, we decided to test its… CONTINUE READING

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