Association between depression severity and neurocognitive function in major depressive disorder: a review and synthesis.

@article{McClintock2010AssociationBD,
  title={Association between depression severity and neurocognitive function in major depressive disorder: a review and synthesis.},
  author={Shawn M. McClintock and Mustafa M. Husain and Tracy L. Greer and C. Munro Cullum},
  journal={Neuropsychology},
  year={2010},
  volume={24 1},
  pages={
          9-34
        }
}
The effects of major depressive disorder (MDD) on neurocognitive function remain poorly understood. Results from published studies vary widely in terms of methodological factors, and very little is known about the effects of depression severity and other clinical characteristics on neurocognitive function. The purpose of this review was to synthesize prior research findings regarding neurocognitive functioning in patients with MDD and varying levels of depression severity and to provide… 

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References

SHOWING 1-10 OF 170 REFERENCES

Neurocognitive impairment in drug-free patients with major depressive disorder

Pronounced neurocognitive impairment was found in this sample of young adult out-patients with MDD, and could therefore provide an objective marker of brain dysfunction in depression.

Cognitive deficits in depression: Possible implications for functional neuropathology

A focus on the interactions between motivation, affect and cognitive function may allow greater understanding of the interplay between key aspect of the dorsal and ventral aspects of the prefrontal cortex in depression.

A preliminary profile of neuropsychological deficits associated with major depression.

  • H. Veiel
  • Psychology, Biology
    Journal of clinical and experimental neuropsychology
  • 1997
Both the severity and the profile of cognitive deficiencies in depression are postulated to be similar to those seen in moderately severe traumatic brain injury.

Neuropsychological differences between late-onset and recurrent geriatric major depression.

It is suggested that recurrent and late-onset geriatric major depressive disorder may represent distinct phenomenological entities, and phenomenological differences as a function of lifetime history of major depression can guide research in the neurophysiology, prevention, and treatment of geriatricmajor depression.

Cognitive functions in depressive disorders: evidence from a population-based study

Examination of cognitive functioning in population-based samples indicates that persons with depressive disorders in the population exhibit cognitive impairments in tasks tapping episodic memory and mental flexibility and that cognitive impairment varies as a function of depressive disorder.

Neuropsychological functioning in major depression and responsiveness to selective serotonin reuptake inhibitors antidepressants.

Mood and neuropsychological function in depression: the role of corticosteroids and serotonin

It is argued that there is a neurobiological cause of impaired neuropsychological function in depression, particularly in the hippocampus with involvement of serotonergic 5-HT1A and glucocorticoid receptors, and the affective and psychological changes of depressive illness are likely to have complex relationships in time and severity.

Neurocognitive profiles in elderly patients with frontotemporal degeneration or major depressive disorder

Major depressive disorder (MDD) and frontotemporal dementia (FTD) are both disorders in elderly populations that involve the prefrontal cortex and appear to have similar neurocognitive deficits. This

Neuropsychological Correlates of Major Depression: A Short-term Follow-up

The present study investigated neuropsychological correlates of major depression and their course following treatment. We investigated 41 patients with major depression according to DSM-III-R
...