Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC.

@article{Overmeer2008AssociationBD,
  title={Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC.},
  author={Ren{\'e}e M Overmeer and Florianne E. Henken and Peter J. F. Snijders and Debbie Claassen-Kramer and Johannes Berkhof and Theo J. M. Helmerhorst and Dani{\"e}lle A M Heideman and Saskia M. Wilting and Yoshinori Murakami and Akihiko Ito and Chris J L M Meijer and Renske D. M. Steenbergen},
  journal={The Journal of pathology},
  year={2008},
  volume={215 4},
  pages={388-97}
}
We previously showed that silencing of TSLC1, recently renamed CADM1, is functionally involved in high-risk HPV-mediated cervical carcinogenesis. CADM1 silencing often results from promoter methylation. Here, we determined the extent of CADM1 promoter methylation in cervical (pre)malignant lesions and its relation to anchorage-independent growth and gene silencing to select a CADM1-based methylation marker for identification of women at risk of cervical cancer. Methylation-specific PCRs… CONTINUE READING

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