Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women

@article{Barbosa2008AssociationBD,
  title={Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women},
  author={Patr{\'i}cia R Barbosa and Sally P. Stabler and Andr{\'e} Luiz Machado and Ricardo Cerqueira Campos Braga and Rosario Dominguez Crespo Hirata and Mario Hirouki Hirata and Luiz F Sampaio-Neto and Robert H. Allen and Elvira Maria Guerra-Shinohara},
  journal={European Journal of Clinical Nutrition},
  year={2008},
  volume={62},
  pages={1010-1021}
}
Objectives:To examine the association between methylenetetrahydrofolate reductase (MTHFR) (C677T and A1298C), methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G gene polymorphisms and total homocysteine (tHcy), methylmalonic acid (MMA) and S-adenosylmethionine/S-adenosylhomocysteine (SAM/SAH) levels; and to evaluate the potential interactions with folate or cobalamin (Cbl) status.Subjects/Methods:Two hundred seventy-five healthy women at labor who delivered full-term… CONTINUE READING

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