Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy

@article{Capuron2002AssociationBD,
  title={Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy},
  author={Lucile Capuron and Alain Mure Ravaud and Pierre J Neveu and Andrew H. Miller and Michael Maes and Robert Dantzer},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={468-473}
}
Cytokine therapy for cancer or viral diseases is accompanied by the development of depressive symptoms in a significant proportion of patients. Despite the increasing number of studies on the neurotoxic effects of cytokines, the mechanisms by which cytokines induce depressive symptoms remain largely unknown. In view of the relationship between neurotransmitter precursors and mood, the present study aimed at assessing the relationship between serum concentrations of the amino acids tryptophan… CONTINUE READING

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