Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice

@article{Wilkinson2012AssociationBC,
  title={Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice},
  author={Lorine Wilkinson and Nyoman D. Kurniawan and Yu Leng Phua and Michael J Nguyen and Joan Li and Graham J. Galloway and Hikaru Hashitani and Richard J. Lang and Melissa H. Little},
  journal={The Journal of Pathology},
  year={2012},
  volume={227}
}
Crim1 hypomorphic (Crim1$^{KST264/KST264}$) mice display progressive renal disease characterized by glomerular defects, leaky peritubular vasculature, and progressive interstitial fibrosis. Here we show that 27% of these mice also present with hydronephrosis, suggesting obstructive nephropathy. Dynamic magnetic resonance imaging using Magnevist showed fast development of hypo‐intense signal in the kidneys of Crim1$^{KST264/KST264}$ mice, suggesting pooling of filtrate within the renal… Expand
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