Association between coding variability in the LRP gene and the risk of late-onset Alzheimer’s disease

@article{WavrantDeVrize1999AssociationBC,
  title={Association between coding variability in the LRP gene and the risk of late-onset Alzheimer’s disease},
  author={Fabienne Wavrant-DeVri{\`e}ze and J Y Lambert and L. Stas and Richard C Crook and Dominique Cottel and Florence Pasquier and Bernard Frigard and Martine Lambrechts and Els Thiry and Philippe Amouyel and Jordi P{\'e}rez-Tur and M. C. Chartier-Harlin and John S. Hardy and F. Van Leuven},
  journal={Human Genetics},
  year={1999},
  volume={104},
  pages={432-434}
}
We have sequenced the entire (89 exons) open reading frame of the LRP gene in 12 cases of Alzheimer’s disease (AD) from Northern France. We have found no novel changes but confirm the occurrence of a polymorphism in exon 6 of the gene (A216V). This polymorphism is rare (2.8% of controls) and is in linkage equilibrium with previously reported polymorphisms. The V216 allele is negatively associated with the disease in a large case-controlled series. These data suggest that the LRP receptor may be… CONTINUE READING

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