Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas

@article{Sb2005AssociationBC,
  title={Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas},
  author={Mona S{\ae}b{\o} and Camilla Furu Skjelbred and Rebecca Breistein and Inger Marie Bowitz Lothe and Per Christian Hagen and Gunter Bock and I. L. Hansteen and Elin H. Kure},
  journal={BMC Cancer},
  year={2005},
  volume={6},
  pages={71 - 71}
}
BackgroundThe association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous polyposis coli (APC) gene has been reported to have a "gatekeeper" function in the colonic mucosa.MethodsTo evaluate the hypothesis that cigarette smoking is associated with adenoma and carcinoma development and further to investigate whether this association is due to… CONTINUE READING
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