Association between chemotherapy and cognitive impairments in a large cohort of patients with colorectal cancer.

@article{Du2013AssociationBC,
  title={Association between chemotherapy and cognitive impairments in a large cohort of patients with colorectal cancer.},
  author={Xianglin L. Du and Yi Cai and Elaine Symanski},
  journal={International journal of oncology},
  year={2013},
  volume={42 6},
  pages={
          2123-33
        }
}
No population-based study has been conducted on the relationship between chemotherapy and the risk of cognitive impairments in patients with colorectal cancer. This study aimed to determine this association in a large population-based cohort of patients. We studied 72,374 men and women who were diagnosed with stages I-III colorectal cancer at age ≥ 65 years from 1991 through 2002 from 16 regions in the Surveillance, Epidemiology and End Results program who were free of cognitive impairments at… 
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Self-Reported History of Chemotherapy and Cognitive Decline in Adults Aged 60 and Older: The PATH Through Life Project.
TLDR
Results suggest chemotherapy prior to old age is associated with faster decline in memory in late life but that it does not affect decline in other domains of cognitive function.
Chemotherapy-induced cognitive changes
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Chemotherapy-induced cognitive changes in cancer survivors is described, which may provide a method to decrease the emotional burden of survivorship in clinical practice and the complex interaction between these psycho-emotional factors is interpreted within the framework of cognitive-behavioural therapies.
Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview
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New data about common mechanisms in etiopathology of cancer and neurological diseases suggests new therapeutic strategies and the use of nilotinib, tyrosine kinase inhibitor, protein kinase C, and bexarotene is the most promising.
Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways
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The review proposes a hypothesis, according to which several molecular players, prominently PIN1 and p53, have been investigated and considered involved in complex molecular interactions putatively associated with the inverse correlation, and PIN1 may be identified as a novel key regulator at the crossroad between cancer and AD.
Inverse correlation between Alzheimer’s disease and cancer: implication for a strong impact of regenerative propensity on neurodegeneration?
TLDR
The reduced prevalence of AD in cancer survivors may implicate a strong impact of aberrant neural regenerative burden in neurodegeneration, and this negative correlation reflects a rebalance of biosynthetic propensity between body systems under the two disease statuses.
Cannabinoid Drugs-Related Neuroprotection as a Potential Therapeutic Tool Against Chemotherapy-Induced Cognitive Impairment
TLDR
The neuroprotective role of the ECS, well described in other cognitive-related neuropathologies, seems to be able to reduce the activation of pro-inflammatory cytokines involved in the neuroinflammatory supraspinal processes underlying CICI.
Drug-Induced Disorders of Memory and Dementia
  • K. Jain
  • Psychology, Biology
    Drug-induced Neurological Disorders
  • 2021
TLDR
Various pathomechanisms of drug-induced memory deficits are discussed in this article and it is suggested that memory training exercises may accelerate the recovery.
Perceived Barriers and Facilitators for Return to Work Among Colorectal Cancer Survivors: Malaysian Healthcare Professionals Experience-　A Qualitative Inquiry.
TLDR
Key facilitators identified were desire to resume working life and to contribute to society, financial pressure, maintain organizational health insurance, less physically demanding job, supportive workplace and strict organizational policy on medical leaves.
FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma
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The results of the present study indicate that FBXL20 may mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells.
Risk of dementia in colorectal cancer patients receiving chemotherapy: A nationwide cohort study

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