Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.

@article{Jung2004AssociationBC,
  title={Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.},
  author={Carla Sabine Jung and Brian A Iuliano and Judith Harvey-White and Michael Graham Espey and Edward Hudson Oldfield and Ryszard M. Pluta},
  journal={Journal of neurosurgery},
  year={2004},
  volume={101 5},
  pages={836-42}
}
OBJECT Decreased availability of nitric oxide (NO) has been proposed to evoke delayed cerebral vasospasm after sub-arachnoid hemorrhage (SAH). Asymmetric dimethyl-L-arginine (ADMA) inhibits endothelial NO synthase (eNOS) and, therefore, may be responsible for decreased NO availability in cases of cerebral vasospasm. The goal of this study was to determine whether ADMA levels are associated with cerebral vasospasm in a primate model of SAH. METHODS Twenty-two cynomolgus monkeys (six control… CONTINUE READING
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