Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.

Abstract

It has been suggested that symptoms of attention-deficit/hyperactivity disorder (ADHD) is related to low dopamine levels in the prefrontal cortex. The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680… (More)
DOI: 10.1002/ajmg.b.30831

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