Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder.

@article{Lachman1998AssociationBC,
  title={Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder.},
  author={Herbert M. Lachman and Karen Ann Nolan and Pavel Mohr and T. Saito and Jan Volavka},
  journal={The American journal of psychiatry},
  year={1998},
  volume={155 6},
  pages={
          835-7
        }
}
OBJECTIVE The authors previously reported a relationship between an allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behavior in schizophrenic patients. This study replicates and extends these findings by using more direct measures of violent behavior. METHOD Fifty-five white patients (34 men, 21 women) with DSM-IV diagnoses of schizophrenia or schizoaffective disorder were selected to form two groups (violent and nonviolent) on the basis of… Expand
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TLDR
No association was observed between homicidal behavior in schizophrenic patients and the dopamine D4 exon III repeat length polymorphism (D4DR) and the serotonin transporter promoter-region polymorphisms (5-HTTLPR). Expand
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TLDR
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TLDR
A significant combined effect was seen: the cases with concurrent family history of schizophrenia and the COMT-L allele containing genotypes had an almost 4-fold (OR=3.9, 95% CI=1.1-14.3) higher risk of schizophrenia compared to controls with theCOMT-HH genotypes. Expand
Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype
TLDR
The high-activity COMT homozygote confers a higher risk of recorded aggression in schizophrenia and Heterozygotes had a significantly lower risk, which may represent an example of heterosis/heterozygote advantage. Expand
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TLDR
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TLDR
The Met158 allele of the COMT gene confers a significantly increased risk for aggressive and violent behavior in schizophrenia, and may provide basis for developing informative strategies for reducing violence in patients with schizophrenia. Expand
Catechol‐O ‐methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis
TLDR
The findings indicate that COMT gene polymorphisms were not statistically significant between patient and control groups, however, the patients with the L/L genotype may have much more severe clinical signs in Turkish schizophrenics. Expand
Analysis of an association between the COMT polymorphism and clinical symptomatology in schizophrenia
TLDR
It may be suggested that a modifying gene may be required in order for the COMT polymorphism to manifest at the clinical level in schizophrenia with one set of susceptibility genes being more sensitive to COMT enzyme variability than others. Expand
Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population
TLDR
Findings support the hypothesized moderating role of the COMT gene in the aggressive behaviour in some schizophrenic patients, though they do not support the existence of a direct association between the COMt Val158Met polymorphism and aggressive schizophrenia case status in the Korean population. Expand
Association of aggressive behavior in Korean male schizophrenic patients with polymorphisms in the serotonin transporter promoter and catecholamine-O-methyltransferase genes
TLDR
The COMT gene is associated with the severity of aggression and with physical aggression against other people, whereas the 5-HTTPR gene isassociated with the summary score of all episodes of aggression. Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior
TLDR
It is found that schizophrenic patients who are homozygous for the low activity allele were judged by their psychiatrists to be at higher risk for aggressive and dangerous behavior than those who were homozygously for the high activity allele. Expand
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.
TLDR
It is shown that a common functional allele of this gene, which results in a 3- to 4-fold reduction in enzyme activity, is significantly associated in a recessive manner with susceptibility to OCD, particularly in males. Expand
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
TLDR
The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur. Expand
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.
TLDR
Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression. Expand
Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.
TLDR
Red blood cell COMT activity is significantly higher in black subjects than white subjects, and Hardy-Weinberg estimates indicate that this ethnic difference is due to a higher frequency of high activity COMT alleles in blacks vs. whites. Expand
Can aggressive behavior in humans be modified by beta blockers?
TLDR
A review of several studies in which both old and young aggressive patients with various organic brain disorders received propranolol showed that aggressive behavior was reduced in 75 (86%) of 87 patients, encouraging because none of the patients had responded to earlier drug treatment. Expand
Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.
TLDR
In a population of patients with VCFS, there is an apparent association between the low-activity allele, COMT158met, and the development of bipolar spectrum disorder, and in particular, a rapid-cycling form. Expand
Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.
TLDR
Catechol-O-methyltransferase activity was measured in blood obtained from 373 randomly selected subjects aged 16-18, 262 consecutive adult blood donors, and 201 first-degree relatives of subjects with RBC COMT activity of less than 8 U and the results of segregation analyses of the data were compatible with autosomal recessive inheritence of an allele for low RBCCOMT activity. Expand
Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland.
TLDR
The catechol-O-methyltransferase (COMT) gene occurs as two polymorphic alleles, which code for a high activity thermostable and low activity thermolabile form of the enzyme, which are shown to be equally distributed in the Finnish population. Expand
Human liver catechol‐O‐methyltransferase pharmacogenetics
TLDR
Findings indicate that the genetic polymorphism that controls catechol‐O‐methyltransferase activity level and thermal stability in red blood cells also controls those same properties of the enzyme in the human liver. Expand
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