Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematologic stem cell transplantation.

@article{Bartelink2009AssociationBB,
  title={Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematologic stem cell transplantation.},
  author={Imke Heleen Bartelink and Robert G M Bredius and Svetlana V. Belitser and Marit M. Suttorp and Marc Bierings and Catherijne A J Knibbe and R. Maarten Egeler and Arjan C Lankester and Atoine C G Egberts and Juliette Zwaveling and Jaap Jan Boelens},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2009},
  volume={15 2},
  pages={231-41}
}
Busulfan, combined with therapeutic drug monitoring-guided dosing, is associated with higher event-free survival (EFS) rates due to fewer graft failures/relapses and lower toxicity. The optimal target area under the curve (AUC) and dosing schedule of intravenous busulfan in children undergoing hematopoietic stem cell transplantation (HSCT) remain unclear, however. We conducted a retrospective analysis of the association between busulfan exposure and clinical outcome in 102 children age 0.2 to… CONTINUE READING

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Evaluation of 2 i.v. busulfan pediatric dosing guidelines

  • LL Dupuis, T Schechter, M Ansari
  • Biol Blood Marrow Transplant. 2008;14:167. ix f…
  • 2009
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