Association between blood pressure variability, cardiovascular disease and mortality in type 2 diabetes: A systematic review and meta‐analysis

@article{Chiriac2019AssociationBB,
  title={Association between blood pressure variability, cardiovascular disease and mortality in type 2 diabetes: A systematic review and meta‐analysis},
  author={Martina Chiriac{\`o} and Konstantinos Pateras and Agostino Virdis and Marietta Charakida and Dimitra Kyriakopoulou and Monica Nannipieri and Michele Emdin and Constantinos Tsioufis and Stefano Taddei and Stefano Masi and Georgios Georgiopoulos},
  journal={Diabetes},
  year={2019},
  volume={21},
  pages={2587 - 2598}
}
To investigate the associations of blood pressure variability (BPV), expressed as long‐term (visit‐to‐visit) and short‐term (ambulatory blood pressure monitoring [ABPM] and home blood pressure monitoring [HBPM]) and all‐cause mortality, major adverse cardiovascular events (MACEs), extended MACEs, microvascular complications (MiCs) and hypertension‐mediated organ damage (HMOD) in adult patients with type 2 diabetes. 
Long‐term variability of blood pressure and incidence of heart failure among individuals with Type 2 diabetes
TLDR
This association of long‐term variability of blood pressure with incident heart failure in individuals with Type 2 diabetes is evaluated in a large community‐based sample of adults with Type 1 diabetes.
Blood pressure visit‐to‐visit variability and outcomes in patients with heart failure with preserved ejection fraction
TLDR
This study sought to explore the association between visit‐to‐visit variability (VVV) of BP and clinical outcomes in patients with HFpEF.
Long-Term Variability of Blood Pressure, Cardiovascular Outcomes, and Mortality: The Look AHEAD Study.
TLDR
In a large sample of individuals with type 2 diabetes, a greater variability in SBP was associated with higher cardiovascular mortality and CVD events; a higher variability in DBP was linked to increased overall and cardiovascular mortality.
Blood Pressure Variability and Diabetes Mellitus
TLDR
The primary goal of antihypertensive treatment in patients with type 2 diabetes shall remain to controll mean blood pressure levels, however, when future studies show consistent results, BPV might be regarded as a therapeutic target in type 2 diabetic patients.
Baseline blood pressure modifies the role of blood pressure variability in mortality: Results from the ACCORD trial
TLDR
The relationship between systolic and diastolic BPv and risk of all-cause and cardiovascular mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was examined in posthoc analyses by clinically relevant categories of baseline blood pressure, and the association between BPv in cardiovascular and noncardiovascular mortality was compared.
Association between visit-to-visit variability of glycemic indices and lipid profile and the incidence of coronary heart disease in adults with type 2 diabetes
TLDR
Visit to visit variability of glycemic indices of the patients with type 2 diabetes is associated with incident CHD independent of their baseline and mean values.
Refining determinants of associations of visit-to-visit blood pressure variability with cardiovascular risk: results from the Action to Control Cardiovascular Risk in Diabetes Trial
TLDR
The effect of BPv on adverse cardiovascular (but not cerebrovascular) outcomes is modified by baseline blood pressure and prior CVD, and recognition of more nuanced relationships may help improve risk stratification and blood pressure management decisions.
Prognostic importance of visit-to-visit blood pressure variability for micro- and macrovascular outcomes in patients with type 2 diabetes: The Rio de Janeiro Type 2 Diabetes Cohort Study
TLDR
The goal of anti-hypertensive treatment in patients with type 2 diabetes shall remain in controlling mean BP levels, not on decreasing their visit-to-visit variability, and no BP-VVV parameter significantly improved cardiovascular risk discrimination.
Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT
TLDR
Blood pressure variability is associated with HF risk in individuals with type 2 diabetes, possibly a consequence of periods of ischemia during diastole, and may have implications for optimizing blood pressure treatment strategies in those with type 1 diabetes.
Prognostic impact of short-term ambulatory blood pressure variability for microvascular and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro Type 2 Diabetes Cohort Study.
TLDR
Short-term BPV, particularly daytime DBPV, predicts future development of macrovascular complications and mortality and improves cardiovascular risk discrimination in patients with diabetes.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 132 REFERENCES
Visit-to-Visit Blood Pressure Variability and Mortality and Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study
TLDR
Visit-to-visit DBP variability and considerable changes in DBP and SBP were risk factors for mortality in the elderly and were related to higher all-cause and CV mortality.
The Role of Blood Pressure Variability in the Development of Nephropathy in Type 1 Diabetes
TLDR
Visit-to-visit variability in blood pressure consistently independently added to mean blood pressure in predicting the risk of nephropathy, but not retinopathy, in the DCCT, which could have implications for the management and treatment ofBlood pressure in patients with type 1 diabetes.
Blood Pressure Variability and Risk for Progression of Cardiovascular and Renal Diseases in Patients with Diabetes Mellitus
TLDR
A review of the prognostic importance of BP variability in hypertensive patients with diabetes mellitus shows increased variability of systolic and/or diastolic BP within one day and also over longer periods is associated with target-organ damage and cardiovascular events.
Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes Mellitus: The ADVANCE-ON Study
TLDR
Visit-to-visit variability in SBP is an independent predictor of vascular complications and death, which improves risk prediction beyond that provided by traditional risk factors, including mean SBP.
Visit‐to‐visit HbA1c variability and systolic blood pressure (SBP) variability are significantly and additively associated with mortality in individuals with type 1 diabetes: An observational study
TLDR
To investigate the relationship between variability in both visit‐to‐visit HbA1c and SBP and mortality in individuals with type 1 diabetes, a large number of patients with type 2 diabetes were referred to the clinic.
PP.03.25: RELATIONSHIP BETWEEN 24-HOUR BLOOD PRESSURE VARIABILITY AND TARGET ORGAN DAMAGE IN PATIENTS WITH TYPE 2 DIABETES
TLDR
Results indicate that high short-term BP variability may be a marker for renal and/or cardiovascular complications in type 2 diabetes and Elevation of 24SBPCV may indicate higher risk for the progression of diabetic nephropathy.
Visit-to-Visit Blood Pressure Variability Is a Novel Risk Factor for the Development and Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes
TLDR
Visit-to-visit variability in SBP could be a novel risk factor for the development and progression of diabetic nephropathy in patients with type 2 diabetes.
Night time blood pressure variability is a strong predictor for cardiovascular events in patients with type 2 diabetes.
TLDR
Night time BP variability was an independent predictor of future incidence of CVD, suggesting that this measure could reflect pathophysiology of T2DM.
Prognostic impact of systolic blood pressure variability in people with diabetes
TLDR
Although BPV was independently associated with all-cause mortality in diabetes patients in primary care who did not have pre-existing cardiovascular disease or BP-lowering drugs, it may be of minimal clinical usefulness above and beyond that of other routinely measured predictors, including mean BP.
...
1
2
3
4
5
...