• DOI:10.1016/0028-3908(66)90038-4
Corpus ID: 6327469

Association between biochemical and behavioral actions of tricyclic antidepressants.

@article{Murad1966AssociationBB,
  title={Association between biochemical and behavioral actions of tricyclic antidepressants.},
  author={J. E. Murad and P. A. Shore},
  journal={International journal of neuropharmacology},
  year={1966},
  volume={5 4},
  pages={
          299-304
        }
}

J. E. Murad, P. A. Shore

Published 1966

Chemistry, Medicine

International journal of neuropharmacology

Abstract Adrenergic neurones of rats were labelled with metaraminol, an amine which is not a substrate of monoamine oxidase or catechol-o-methyl transferase. Injection of tetrabenazine or any of four tricyclic antidepressant drugs had no significant effect on metaraminol levels, but injection of tetrabenazine in the presence of certain antidepressants markedly lowered heart or brain metaraminol levels. The range of activity of the antidepressants in this system correlates with antidepressant… CONTINUE READING

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