Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.

@article{Croitoru2004AssociationBB,
  title={Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.},
  author={Marina E Croitoru and Sean P. Cleary and Nando Di Nicola and Michael Manno and Teresa Selander and Melyssa D. Aronson and Mark Redston and Michelle Cotterchio and J. A. G. Knight and Robert Gryfe and Steven Gallinger},
  journal={Journal of the National Cancer Institute},
  year={2004},
  volume={97 4},
  pages={320-1; author reply 321-2}
}
The MutY human homologue (MYH) gene encodes a member of the base excision repair pathway that is involved in repairing oxidative damage to DNA. Two germline MYH gene mutations that result in Myh proteins containing amino acid substitutions Y165C and G382D (hereafter called the Y165C and G382D mutations) are associated with adenomatous poly-posis and colorectal cancer among patients from several European poly-posis registries. We used a population-based series of 1238 colorectal cancer patients… CONTINUE READING
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