Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene

@article{Szalai2002AssociationBB,
  title={Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene},
  author={Alexander Szalai and Mark A. McCrory and G. S. Cooper and J Wu and Robert Kimberly},
  journal={Genes and Immunity},
  year={2002},
  volume={3},
  pages={14-19}
}
Elevation of baseline C-reactive protein (CRP) is associated with increased risk of cardiac disease. This increase might reflect low-grade inflammation, but differences in CRP serum levels might also have a genetic component. To test this possibility, we investigated whether a polymorphic GT-repeat in the intron of the CRP gene contributes to variation in baseline CRP. We found that the polymorphism was associated with differences in baseline CRP in both normal individuals and in patients with… CONTINUE READING