Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor
@article{Shirakawa1994AssociationBA, title={Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor}, author={T. Shirakawa and Airong Li and M. Dubowitz and J. Dekker and A. E. Shaw and J. Faux and C. Ra and W. Cookson and J. Hopkin}, journal={Nature Genetics}, year={1994}, volume={7}, pages={125-130} }
The β–subunit of the high–affinity IgE receptor (FcεRI–β) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of FcεRI–β, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally… Expand
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