Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

@article{Shirakawa1994AssociationBA,
  title={Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor},
  author={T. Shirakawa and Airong Li and M. Dubowitz and J. Dekker and A. E. Shaw and J. Faux and C. Ra and W. Cookson and J. Hopkin},
  journal={Nature Genetics},
  year={1994},
  volume={7},
  pages={125-130}
}
The β–subunit of the high–affinity IgE receptor (FcεRI–β) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of FcεRI–β, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally… Expand
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