Association between an interleukin-13 promoter polymorphism and atopy.

  title={Association between an interleukin-13 promoter polymorphism and atopy.},
  author={Tina Hummelshoj and Uffe Bodtger and Pameli Datta and Hans-J\orgen Malling and Annette Bang Oturai and Lars K{\ae}rgaard Poulsen and Lars Peter Ryder and Per Soelbeg Sorensen and Else Lyngs\oe Svejgaard and Arne Svejgaard},
  journal={European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics},
  volume={30 5},
Several studies indicate genetic involvement of Th2 cytokines in allergic diseases. Interleukin (IL)-13 has been mapped to the cytokine cluster on chromosome 5q31-33, which has been associated with atopic conditions. Recently, an association was reported between the T allele in a promoter polymorphism in the IL-13 gene (C to T exchange) at position -1055 and allergic asthma in a population study in the Netherlands. This observation was apparently confirmed in a case-control study using probands… CONTINUE READING


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