Association between alveolar macrophage plasminogen activator activity and indices of lung function in young cigarette smokers.

@article{Reilly1988AssociationBA,
  title={Association between alveolar macrophage plasminogen activator activity and indices of lung function in young cigarette smokers.},
  author={John J. Reilly and Harold A Chapman},
  journal={The American review of respiratory disease},
  year={1988},
  volume={138 6},
  pages={1422-8}
}
Recent evidence suggests that connective tissue breakdown in the human lung leading to airway obstruction and emphysema involves proteinases expressed by neutrophils and macrophages that traffic to the lungs in response to cigarette smoke. It remains unclear why only a small fraction of all cigarette smokers develop symptomatic airway obstruction. In this study, we examined indexes of inflammation and proteolytic activity in samples of bronchoalveolar lavage from young cigarette smokers and… CONTINUE READING