Association between activated renin angiotensin system and bone formation in hemodialysis patients: is the bone mass genetically determined by ACE gene polymorphism?

@article{Altun2004AssociationBA,
  title={Association between activated renin angiotensin system and bone formation in hemodialysis patients: is the bone mass genetically determined by ACE gene polymorphism?},
  author={B{\"u}lent Altun and Ahmet Alper Kiykim and Volkan Seyrantepe and Celalettin Usalan and Mustafa Arıcı and Meltem Çağlar and Yunus Erdem and Unal Yasavul and Çetin Turgan and S. H. Caglar},
  journal={Renal failure},
  year={2004},
  volume={26 4},
  pages={
          425-31
        }
}
BACKGROUND Angiotensin II (ang II) receptor subtype I binding sites has been recently demonstrated on bone cell precursors. Ang II stimulates DNA and collagen synthesis in human adult bone cells. The aim of this study is to evaluate the role of renin angiotensin system in the bone metabolism and to address the genetic influence of angiotensin converting enzyme (ACE) gene polymorphism on bone mass in hemodialysis patients. METHODS Forty-eight end-stage renal disease patients (28 male, 20… CONTINUE READING