Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis.


A longitudinal cohort study of sexually active women 18-30 years of age was conducted to identify variables associated with the acquisition of herpes simplex virus type 2 (HSV-2) infections. Six hundred seventy HSV-2-seronegative women were followed up at 4-month intervals for 1 year; acquisition of HSV-2 antibodies was detected in 32 of these women. Black race, < or =12 years of education, having a new sex partner, and bacterial vaginosis (BV) were associated with HSV-2 seroconversion on univariate analysis. Antecedent HSV-1 infection was not protective against HSV-2 acquisition. After controlling for other identified risk factors in multivariable models, the diagnosis of BV remained associated with an increased risk of acquiring HSV-2 infection (hazard ratio, 2.1; 95% confidence interval, 1.0-4.5; P=.05). In this study, the population attributable risk of BV for HSV-2 seroconversion was 21%. Additional studies are needed to determine whether screening and treatment of BV could reduce susceptibility to the acquisition of HSV-2 in women.

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@article{Cherpes2003AssociationBA, title={Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis.}, author={Thomas L. Cherpes and Leslie A. Meyn and Marijane A . Krohn and Joel G Lurie and Sharon Louise Hillier}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={2003}, volume={37 3}, pages={319-25} }