Association between a variant of the glutathione S-transferase P1 gene (GSTP1) and hypertension in pregnancy in Japanese: interaction with parity, age, and genetic factors.

@article{Ohta2003AssociationBA,
  title={Association between a variant of the glutathione S-transferase P1 gene (GSTP1) and hypertension in pregnancy in Japanese: interaction with parity, age, and genetic factors.},
  author={Kaori Ohta and G. Kobashi and Akira Hata and Hideto Yamada and Hisanori Minakami and Seiichiro Fujimoto and Kiyotaro Kondo and Hiko Tamashiro},
  journal={Seminars in thrombosis and hemostasis},
  year={2003},
  volume={29 6},
  pages={653-9}
}
Hypertension in pregnancy (HP), including preeclampsia (PE), is known to be a multifactorial disease. Recently, an Ile105Val variant of the glutathione S-transferase P1 gene ( GSTP1) was shown to be associated with PE in The Netherlands. We therefore performed an association study of the Ile105Val variant comparing 131 patients with HP and 327 normal pregnant controls in Japan. We analyzed the data in the context of other risk factors before pregnancy. The frequency of the Ile/Val+Val/Val… CONTINUE READING
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