Association between a synonymous SNP (rs470558, Ala216Ala) of MMP1 and schizophrenia with auditory hallucinations in Korean population

@article{Kim2012AssociationBA,
  title={Association between a synonymous SNP (rs470558, Ala216Ala) of MMP1 and schizophrenia with auditory hallucinations in Korean population},
  author={Jong Woo Kim and Won Sub Kang and Sang Min Lee and Su Kang Kim and Hae Jeong Park and Geum-hee Gwak and Hyung Hwan Baik},
  journal={Molecular & Cellular Toxicology},
  year={2012},
  volume={8},
  pages={297-302}
}
Extracellular matrix (ECM) abnormality is implicated in the pathogenesis of schizophrenia. Matrix metalloproteinases (MMPs) mediate the proteolysis of ECM and may play a crucial role in neuronal plasticity. We investigated whether single nucleotide polymorphisms (SNPs) of MMP1 and MMP8 are associated with the development of schizophrenia. We also assessed the relationships between MMP1, MMP8 SNPs and the core symptoms of schizophrenia such as persecutory delusion, auditory hallucinations… CONTINUE READING