Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

@article{Reuter2007AssociationBA,
  title={Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.},
  author={Martin Reuter and Yvonne Kuepper and Juergen Hennig},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 3},
  pages={401-4}
}
In a genetic association study the role of the -703 G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703 G/T polymorphism was detected supporting the findings by Gutknecht and colleagues.