Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.

Abstract

Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.

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@article{Ho2004AssociationBA, title={Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.}, author={Hoi-Por Ho and Lars Westberg and Kristina Annerbrink and Marie Olsson and Jonas Melke and Staffan Nilsson and Fariba Baghaei and Roland Rosmond and G{\"{o}ran Holm and Per Bj{\"{o}rntorp and Sven Andersch and Christer Allgulander and Elias Eriksson}, journal={Psychoneuroendocrinology}, year={2004}, volume={29 9}, pages={1138-41} }