Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.

@article{Glatt2003AssociationBA,
  title={Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.},
  author={S. Glatt and S. Faraone and M. Tsuang},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 3},
  pages={
          469-76
        }
}
OBJECTIVE There is strong evidence for a genetic contribution to schizophrenia, but efforts to identify susceptibility genes have been largely unsuccessful because of the low power of individual studies. The authors' goal was to evaluate the collective evidence for an association between the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophrenia. METHOD They performed separate meta-analyses of existing case-control and family-based association studies… Expand
Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case–control studies
TLDR
The results of the meta-analysis do not support an association between the catechol O-methyltransferase (COMT) Val allele and schizophrenia case status, and support recent claims that this association may be moderated by ancestry. Expand
Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis
TLDR
The data provide minimal evidence that the Val allele is a susceptibility factor for schizophrenia in either European or Asian populations. Expand
Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.
TLDR
The COMT gene rs165599 SNP does not appear to be a single-risk factor for schizophrenia, and although the subgroup analyzes reduced the heterogeneity, no association was obtained. Expand
Meta-analysis of association between ApoE ε4 allele and schizophrenia
Several case-control studies have reported an association between schizophrenia and the epsilon4 allele of Apolipoprotein E gene. The results have been equivocal. This meta-analysis has evaluated theExpand
The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects
TLDR
The analyses indicate that there is an association between COMT Val108/158Met and schizophrenia in the general population and in Caucasian populations, this risk could be increased. Expand
Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples
TLDR
A collaborative meta-analysis using both published and unpublished family-based and case-control samples to resolve the role for RGS4 in SCZ susceptibility suggests risk due to at least two common haplotypes in the presence of heterogeneity. Expand
Association of the NRG1 gene and schizophrenia: a meta-analysis
TLDR
It is indicated that firmly establishing the role of NRG1 gene in schizophrenia by genetic association requires much larger sample sizes than have hitherto been reported, and association analyses and replications should take place at the level of the gene, rather than at thelevel of SNP, haplotype, or functional variant. Expand
No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population
TLDR
It is shown that these five functional COMT polymorphisms do not play a major role in conferring susceptibility to schizophrenia in Japanese, and there were no significant associations found between the polymorphisms or haplotypes of COMT and schizophrenia. Expand
No association between schizophrenia and polymorphisms in COMT in two large samples.
TLDR
The data suggest that the valine allele of COMT does not increase susceptibility to schizophrenia in Europeans and that the Ashkenazi or Irish haplotype does notincrease susceptibility, which means that the haplotype data may not generalize across populations. Expand
Association Study of a Functional Catechol-O-Methyltransferase Genetic Polymorphism with Age of Onset, Cognitive Function, Symptomatology and Prognosis in Chronic Schizophrenia
TLDR
The COMT Val158Met polymorphism did not appear to significantly affect susceptibility, symptomatology, global cognitive function and prognosis in Chinese patients with schizophrenia, but the possible association with AOO merits further investigation. Expand
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TLDR
A significant combined effect was seen: the cases with concurrent family history of schizophrenia and the COMT-L allele containing genotypes had an almost 4-fold (OR=3.9, 95% CI=1.1-14.3) higher risk of schizophrenia compared to controls with theCOMT-HH genotypes. Expand
No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.
TLDR
There was no evidence for variation in COMT activity between a group of schizophrenic patients and matched comparison subjects. Expand
Catechol‐O ‐methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis
TLDR
The findings indicate that COMT gene polymorphisms were not statistically significant between patient and control groups, however, the patients with the L/L genotype may have much more severe clinical signs in Turkish schizophrenics. Expand
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TLDR
The data suggest that the COMT gene does not play a major role in the pathogenesis of schizophrenia, and the genotypic overlap between schizophrenia and velocardiofacial syndrome was rare in this cohort. Expand
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TLDR
The hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia is not supported. Expand
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TLDR
Findings may indicate an effect of COMT alleles on susceptibility to schizophrenia, or reflect linkage disequilibrium with a different causative polymorphism in the vicinity. Expand
Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in Taiwan
TLDR
The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide, however, the results showed a significant difference in age at disease onset among different genotypes. Expand
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TLDR
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TLDR
The results do not support the hypothesis that inherited variants of MAO genes might play a major role in a genetic predisposition to schizophrenia and the identification of polymorphisms related to enzyme activity is useful. Expand
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