Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.

@article{Lee2016AssociationBT,
  title={Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.},
  author={Sun Hee Lee and Wan Beom Park and Shinwon Lee and Sohee Park and Shin Woo Kim and Jong-Myung Lee and Hyun Ha Chang and Ki Tae Kwon and Pyoeng Gyun Choe and Nam Joong Kim and Hong Bin Kim and Myoung-don Oh},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 11},
  pages={6928-6932}
}
Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were… CONTINUE READING

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