Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients

  title={Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients},
  author={Yves Gillet and Bertrand Issartel and Philippe Vanhems and J C Fournet and G{\'e}rard Lina and Mich{\`e}le Bes and François Vandenesch and Yves Piémont and Nicole Brousse and Daniel Floret and Jérôme Etienne},
  journal={The Lancet},

The association between Staphylococcus aureus strains carrying panton-valentine leukocidin genes and the development of deep-seated follicular infection.

  • O. YamasakiJ. Kaneko K. Iwatsuki
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
PVL gene-positive S. aureus strains are involved in the development of multiple furuncles with more-intense erythema, particularly in healthy young adults, while PVL gene-negative strains were isolated from patients with various systemic complications, including diabetes, leukemia, and autoimmune diseases.

Presence of Genes Encoding Panton-Valentine Leukocidin Is Not the Primary Determinant of Outcome in Patients with Hospital-Acquired Pneumonia Due to Staphylococcus aureus

This study suggests that neither pvl presence nor in vitro level of alpha-hemolysin production is the primary determinant of outcome among patients with HAP caused by S. aureus.

Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England.

The proportion of staphylococcal infections that are caused by strains containing the PVL genes is estimated, and risk factors for these infections are described, to give consideration to current infection control strategy.

Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

The high case-fatality rate can only be reduced by improving the speed of diagnosis and a rapid test to detect S. aureus in the airways is needed.

Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study

The presence of the PVL toxin does not appear to otherwise influence the natural history of bacteremic S. aureus disease other than in prolonging the duration of fever.

Staphylococcus aureus Isolates Carrying Panton-Valentine Leucocidin Genes in England and Wales: Frequency, Characterization, and Association with Clinical Disease

The PVL genes were also detected in isolates responsible for community-acquired pneumonia, burn infections, bacteremia, and scalded skin syndrome, and the remaining PVL-positive isolates were mostly methicillin-sensitive S. aureus with clinical disease.

Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China.

  • F. YuZ. Chen X. Chen
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2008
There was a high prevalence of PVL genes in genetically diverse S. aureus isolates in Wenzhou, China, and the PVL-positive isolates were associated with lung infection, bloodstream infection and soft-tissue pyogenic infection.



Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia.

  • G. LinaY. Piémont J. Etienne
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1999
Panton-Valentine leukocidin genes were detected in 93% of strains associated with furunculosis and in 85% of those associated with severe necrotic hemorrhagic pneumonia (all community-acquired), and it appears that PVL is mainly associated with nec rotic lesions involving the skin or mucosa.

Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins.

DNA hybridisation of 309 consecutive Staphylococcus aureus clinical isolates with oligonucleotide probes specific for genes encoding Panton-Valentine leucocidin (luk-PV) and gamma-haemolysin (hlg)

The Current Spectrum of Staphylococcus aureus Infection in a Tertiary Care Hospital

Staphylococcus aureus remains a prominent cause of community- and hospital-acquired infection and has a special predilection to cause infections involving prosthetic devices, perhaps related to its affinity for fibronectin, laminin, and other serum proteins that can mediate attachment to foreign material.

Involvement of Enterotoxins G and I in Staphylococcal Toxic Shock Syndrome and Staphylococcal Scarlet Fever

Staphylococcus aureus strains isolated from patients with menstrual and nonmenstrual toxic shock syndrome or staphylitis scarlet fever are reexamined and it is suggested that stAPHylococcal enterotoxins G and I may be capable of causing human staphyllococcal Toxic shock syndrome and staphlyococcal scarlet Fever.

The clinical spectrum of Staphylococcus aureus pulmonary infection.

The results support the concept that S aureus pulmonary infections usually occur in older adults (sixth decade or older) with concomitant illnesses that are typically nosocomial and sputum cultures were found to be sensitive but nonspecific diagnostic tools.

Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities

The cosecretion of these five proteins led to six possible synergistic combinations between F and S components, two of which had dermonecrotic activity on rabbit skin, and all six were leukocytolytic on glass-adsorbed leukocytes.

Breast Milk Transmission of a Panton-Valentine Leukocidin-Producing Staphylococcus aureus Strain Causing Infantile Pneumonia

A 38-day-old infant who developed pleuropneumonia due to a Staphylococcus aureus strain responsible for familial furunculosis, which was acquired by maternal breast-feeding, is reported on.


How rarely Staphylococcus aureus infection of the lung occurs and how grave the prognosis is may best be stated by noting that in a series of about 800 cases of pneumonia, drawn from all classes of the population of New York City, only thirteen cases were treated at the hospital of the Rockefeller Institute under the direction of Dr. Rufus Cole, in.

Bacteremic Staphylococcus aureus pneumonia.

Medical records of 44 consecutive patients with bacteremic Staphylococcus aureus pneumonia between 1980 to 1984 in a 750-bed community teaching hospital were reviewed. 36 patients (82%) were 60 years