Association between Soluble Klotho and Change in Kidney Function: The Health Aging and Body Composition Study.

@article{Drew2017AssociationBS,
  title={Association between Soluble Klotho and Change in Kidney Function: The Health Aging and Body Composition Study.},
  author={David A Drew and Ronit Katz and Stephen B. Kritchevsky and Joachim H. Ix and Michael G. Shlipak and Orlando M Guti{\'e}rrez and Anne B. Newman and Andy N. Hoofnagle and Linda F. Fried and Richard D. Semba and Mark J Sarnak},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2017},
  volume={28 6},
  pages={1859-1866}
}
CKD appears to be a condition of soluble klotho deficiency. Despite known associations between low soluble klotho levels and conditions that promote kidney damage, such as oxidative stress and fibrosis, little information exists regarding the longitudinal association between soluble klotho levels and change in kidney function. We assayed serum soluble α-klotho in 2496 participants within the Health Aging and Body Composition study, a cohort of older adults. The associations between soluble… CONTINUE READING
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