Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients

Abstract

Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes… (More)
DOI: 10.1155/2015/406269

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