Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China

@inproceedings{Ma2017AssociationBS,
  title={Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China},
  author={Xiaowei Ma and Ge Bai and Difei Lu and Linjuan Huang and Jianwei Zhang and Ruifen Deng and Shan Ding and Nan Gu and Xiaohui Guo},
  booktitle={Journal of diabetes research},
  year={2017}
}
Background. Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of the AMP-activated protein kinase (AMPK), plays a crucial role in cardiovascular system. This study aimed to investigate whether genetic variations in the STK11 gene affect the risk of coronary artery disease (CAD) in Chinese type 2 diabetics. Methods. 5 haplotype-tagging single nucleotide polymorphisms (SNPs) were selected, and 288 CAD-positive cases and 159 CAD-negative controls with… CONTINUE READING