Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.

@article{Abe2008AssociationBS,
  title={Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.},
  author={Tomohide Abe and Takayuki Seo and Takateru Ishitsu and Takehiro Nakagawa and Masaharu Hori and K Nakagawa},
  journal={British journal of clinical pharmacology},
  year={2008},
  volume={66 2},
  pages={304-7}
}
AIMS To establish whether the SCN1A IVS5-91 G > A polymorphism of the SCN1A gene, which encodes the neuronal sodium channel alpha subunit, affects responsiveness to the antiepileptic drugs (AEDS) carbamazepine and/or phenytoin. METHODS SCN1A IVS5-91 G > A polymorphism was genotyped in 228 Japanese epileptic patients treated with AEDs. The association between AED responsiveness and the polymorphism was estimated by logistic regression analysis, adjusting for clinical factors affecting the… CONTINUE READING

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