Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players

@article{Guskiewicz2005AssociationBR,
  title={Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players},
  author={Kevin M. Guskiewicz and Stephen W Marshall and Julian E. Bailes and Michael C. McCrea and Robert C. Cantu and Christopher Randolph and Barry D. Jordan},
  journal={Neurosurgery},
  year={2005},
  volume={57},
  pages={719-726}
}
OBJECTIVE:Cerebral concussion is common in collision sports such as football, yet the chronic neurological effects of recurrent concussion are not well understood. The purpose of our study was to investigate the association between previous head injury and the likelihood of developing mild cognitive impairment (MCI) and Alzheimer's disease in a unique group of retired professional football players with previous head injury exposure. METHODS:A general health questionnaire was completed by 2552… 

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References

SHOWING 1-10 OF 51 REFERENCES

Cumulative effects associated with recurrent concussion in collegiate football players: the NCAA Concussion Study.

This study suggests thatPlayers with a history of previous concussions are more likely to have future concussive injuries than those with no history; 1 in 15 players with a concussion may have additional concussions in the same playing season; and previous concussion may be associated with slower recovery of neurological function.

Epidemiology of Concussion in Collegiate and High School Football Players

Players who sustained one concussion in a season were three times more likely to sustain a second concussion in the same season compared with uninjured players, and contact with artificial turf appears to be associated with a more serious concussion than contact with natural grass.

Cumulative Effects of Concussion in High School Athletes

A more severe on-field presentation of concussion markers is evidenced in high school athletes with a pronounced history of concussion, the first to suggest a cumulative effect of concussion in highSchool athletes.

Cumulative effects of concussion in amateur athletes

This study provides preliminary evidence to suggest that athletes with multiple concussions might have cumulative effects of injury, with differences between groups in symptom reporting and memory performance.

Lower cognitive performance of older football players possessing apolipoprotein E epsilon4.

Older professional football players who possessed the APOE epsilon4 allele scored lower on cognitive tests than did players without this allele or less experienced players of any genotype, and the cognitive status of professional athletes with repeated exposure to head trauma may be influenced by age, inherited factors such as APOE genotypes, and cumulative exposure to contact.

Head injury in early adulthood and the lifetime risk of depression.

The risk of depression remains elevated for decades following head injury and seems to be highest in those who have had a severe head injury.

Alzheimer's disease after remote head injury: an incidence study.

Cox proportional hazards modelling showed that a history of head injury with loss of consiousness reported to the physician was associated with earlier onset of dementia due to Alzheimer's disease, consistent with the findings of several case-control studies suggesting that head injury may be a risk factor for Alzheimer's Disease.

The association between head trauma and Alzheimer's disease.

The relation between head trauma and Alzheimer's disease was one of four major risk factors explored in a case-control study of 130 matched pairs; cases were clinically diagnosed at two geriatric psychiatric clinics in Seattle, Washington, and controls were friends or nonblood relatives of the cases.

Head injury and the risk of AD in the MIRAGE study

The influence of head injury on the risk of AD appears to be greater among persons lacking APOE-ε4 compared with those having one or two ε4 alleles, suggesting that these risk factors may have a common biologic underpinning.

Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing.

Preliminary findings suggest that possession of an APOE epsilon4 allele may be associated with increased severity of chronic neurologic deficits in high-exposure boxers.
...