Association between RANK, RANKL and OPG polymorphisms with ACPA and erosions in rheumatoid arthritis: results from a meta-analysis involving three French cohorts

@inproceedings{RuyssenWitrand2016AssociationBR,
  title={Association between RANK, RANKL and OPG polymorphisms with ACPA and erosions in rheumatoid arthritis: results from a meta-analysis involving three French cohorts},
  author={Adeline Ruyssen-Witrand and Yannick Degbo{\'e} and Alain Cantagrel and Delphine Nigon and C{\'e}dric Lukas and Salvatore Scaramuzzino and Yannick Allanore and Olivier Vittecoq and Thierry Schaeverbeke and Jacques Morel and Jean Sibilia and Anne Cambon-Thomsen and Philippe Dieud{\'e} and Arnaud L Constantin},
  booktitle={RMD open},
  year={2016}
}
OBJECTIVES The RANK/RANKL/osteoprotegerin (OPG) system plays a central role in the pathogenesis of bone erosions in rheumatoid arthritis (RA). The aim of this study was to test the association between 11 single-nucleotide polymorphisms (SNPs) located on RANK, RANKL and OPG genes and anticitrullinated peptide antibody (ACPA) presence or erosions in RA. METHODS PATIENTS This work was performed on three independent samples of French patients with RA: the Etude de Suivi des PolyArthrites… CONTINUE READING
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