Association between Promoter Hypomethylation and Overexpression of Autotaxin with Outcome Parameters in Biliary Atresia

@inproceedings{Udomsinprasert2017AssociationBP,
  title={Association between Promoter Hypomethylation and Overexpression of Autotaxin with Outcome Parameters in Biliary Atresia},
  author={Wanvisa Udomsinprasert and Nakarin Kitkumthorn and Apiwat Mutirangura and Voranush Chongsrisawat and Yong Poovorawan and Sittisak Honsawek},
  booktitle={PloS one},
  year={2017}
}
OBJECTIVE Biliary atresia (BA) is a progressive fibroinflammatory liver disease. Autotaxin (ATX) has a profibrotic effect resulting from lysophosphatidic acid activity. The purpose of this study was to examine ATX expression and ATX promoter methylation in peripheral blood leukocytes and liver tissues from BA patients and controls and investigate their associations with outcome parameters in BA patients. METHODS A total of 130 subjects (65 BA patients and 65 age-matched controls) were… CONTINUE READING